Germline influences protein aggregation in somatic tissues
نویسندگان
چکیده
منابع مشابه
Germline MC1R status influences somatic mutation burden in melanoma
The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene. These alleles are also linked to red hair, freckling, and sun sensitivity, all of which are known melanoma phenotypic risk factors. Here we report that in melanomas and for somatic C>T mutations, a signature linked to sun exposure, t...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2021
ISSN: ['1548-4475', '0093-7355']
DOI: https://doi.org/10.1038/s41684-021-00815-x